Dr Sebastian Bass-Stringer is a Senior Research Officer at St Vincent’s Institute of Medical Research (SVI), where he develops human stem cell-derived models of cardiovascular disease to advance therapeutic discovery. His research focuses on developing cardiac microtissues to model biological ageing and patient-specific diseases, including Friedreich’s ataxia-associated cardiomyopathy. By recreating key features of human cardiac disease, he aims to improve preclinical drug testing and identify promising therapies, with a particular interest in developing treatments targeting cellular senescence.
Sebastian completed his PhD at the Baker Heart and Diabetes Institute, where he developed novel gene therapies for heart failure and evaluated their safety and efficacy in preclinical models, including large animals. He subsequently joined the Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) at the Murdoch Children’s Research Institute, where he developed CRISPR-based genetic tools to support the preclinical development and translation of an iPSC-derived cardiac cell therapy. Across his research career, he has authored 13 scientific publications, including eight as first or co-first author, spanning cardiac disease, gene therapy, stem cell biology and regenerative medicine.
Sebastian has received several competitive research awards, including a 2025 SVI Rising Star Award and a 2026 Victorian Cardiovascular Research Network Career Development Grant. He was also runner-up for the Victorian Cardiovascular Research Network’s inaugural Best Published Paper Award in 2025. His research reflects a commitment to advancing human stem cell-based disease modelling and translating fundamental scientific discoveries into more effective therapies for cardiovascular disease.